Noninvasive optoacoustic online retinal temperature determination during continuous-wave laser irradiation.

摘要: The therapeutic effect of most retinal laser treatments is ini- tiated by a transient temperature increase. Although crucial to the effectiveness treatment, course not exactly known due individually different tissue properties. We develop an optoacoustic method determine increase in real time during continuous-wave cw irradiation, and perform calculations interpret results exemplary for transpu- pillary thermotherapy TTT. Porcine globes ex vivo rabbit eyes are irradiated with diode =810 nm, P 3W , =2 mm 60 s. Simultaneously, pulses from N2-laser pumped dye =500 =3.5 ns, E5 J applied on retina. Fol- lowing its absorption, ultrasonic pressure wave emitted, which detected transducer embedded contact lens. Using pre- viously measured temperature-dependent Gruneisen coefficient chorioretinal tissue, raise porcine 5.8 °C/W/cm 2 after s observed confirmed simulta- neous measurements inserted thermocouple. In rabbit, we find 1.4 with, 2.2 without perfusion at same location. Coagulation rabbit's retina occurs T =21 °C 40 conclusion, this seems feasible real-time determination temperature, open- ing possibility feedback control treatments. © 2006 Society Photo-Optical Instrumentation Engineers. DOI: 10.1117/1.2236301