Gd-DTPA-enhanced MR imaging of pituitary adenomas.

摘要: Eleven previously nonoperated patients with suspected pituitary microadenomas were scanned on a 1.5-T GE system before and after administration of IV gadolinium-DTPA (0.1 mmol/kg). Six had Cushing disease, four hyperprolactinemia, one acromegaly. Surgical confirmation was available in all cases, these findings correlated results CT venous sampling, when available. The normal gland, infundibulum, cavernous sinuses enhance immediately the gadolinium-DTPA, allowing contrast between enhancing glandular tissue low-intensity microadenomas. Contrast-enhanced MR detected lesion not seen unenhanced images two disease patient hyperprolactinemia. Tumor delineation improved gadolinium additional cases. In six patients, did significantly alter precontrast interpretation. Adenomas found at surgery 11 patients. tumor correctly localized resulting an accuracy 66.7%. another patient, although focal MR, location adenoma discrepant therefore considered false-positive study. single false-negative examination, both pre- postcontrast failed to detect surgically confirmed microadenoma contrast-enhanced sampling. Correct localization achieved five non-Cushing yielding 100%. Immediate T1-weighted coronal scans most useful detecting intrasellar disease. Delayed obtained 30 min injection improve differentiation gland from microadenoma.(ABSTRACT TRUNCATED AT 250 WORDS)