Prognostic value of p53 overexpression in T1G3 bladder tumors treated with bacillus Calmette-Guérin therapy

摘要: Abstract Objectives. To evaluate the correlation between overexpression of mutant protein p53 and disease recurrence progression in patients treated with bacillus Calmette-Guerin (BCG) intravesical therapy for T1G3 bladder cancer. Methods. We analyzed outcome 29 consecutive tumor transurethral resection. Patients previously a tumor, those who underwent incomplete resection, whom no assessment muscle cell layer was possible were excluded from study. determined using monoclonal p53-DO7 antibody, 20% cutoff definition positivity. After initial all Pasteur BCG (75 mg 50 mL saline), weekly 6 weeks. The assessed by Fisher exact test. Results. median follow-up 36.7 months (range 1 to 108). Of patients, 18 (62.1%) positive 11 (37.9%) negative. Both groups similar according age, tumoral substage (T1a/T1b), association carcinoma situ, multifocality, length follow-up. rate 54.4% p53-negative group versus 38.9% p53-positive ( P = 0.47). 18.2% 33.3% 0.67). Conclusions. These findings suggest that p53, as immunohistochemically, has predictive value cancers BCG.