Prognostic factors in muscle-invasive bladder cancer treated with radiotherapy: an immunohistochemical study
作者： Osen , FossA , Majak , ROtterud , Berner
DOI: 10.1046/J.1464-410X.1998.00657.X
关键词:
摘要: Objective To determine the prognostic role of p53, Ki-67 and p21 for patients with muscle-invasive bladder cancer treated curative intent by radiotherapy. Patients methods The study included 131 (24 women 107 men, median age 72 years, range 40–86) transitional cell carcinoma (T2-T4) external definitive pelvic radiotherapy between 1985 1994. Paraffin-embedded pretreatment biopsies from were examined presence Ki-67, detected immunohistochemistry, related to tumour stage, grade patient survival. Results The expression p53 protein correlated positively detection (P 5% tended live longer than those 5%) independent factors overall survival. Conclusion Further investigation is warranted in undergoing different types treatment. seems play an these patients, addition T category grade.
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