Community respiratory virus infections in immunocompromised patients with cancer.

摘要: Community respiratory viruses, such as syncytial virus (RSV), influenza parainfluenza adenoviruses, and picornaviruses, are an important cause of disease in the immunocompromised adult with cancer. Recent studies have demonstrated that a minimum 31% bone marrow transplant (BMT) recipients 18% adults leukemia who hospitalized acute illness community infection. The temporal occurrence these infections patients tends to mirror their community. clinical illnesses range from self-limited upper fatal pneumonias, depending on type degree immunosuppression. pneumonias may be viral, bacterial/fungal, or mixed. highest frequency progression viral pneumonia has been reported for RSV recently transplanted BMT myelosuppressed leukemia. Studies suggested early therapy combination aerosolized ribavirin intravenous immunoglobulin benefit. Defining effective prophylactic therapeutic strategies will challenge, given diversity wide spectrum varying vulnerability serious disease, frequent presence other opportunistic medical problems. A antiviral drugs immunotherapy need considered potential additive effect well prevent emergence resistant virus, occurs during monotherapy amantadine rimantadine. optimal therapies defined controlled trials; however, it appears favorable response hinge initiation at stage illness.