Management of respiratory viral infections in hematopoietic cell transplant recipients.

作者: Victor E Mulanovich , Shashank S Ghantoji , Roy F Chemaly , Dimpy P Shah , Ella J Ariza-Heredia

DOI:

关键词:

摘要: Advances in stem cell transplantation procedures and the overall improvement clinical management of hematopoietic transplant (HCT) recipients over past 2 decades have led to an increase survival duration, part owing better strategies for prevention treatment post-transplant complications, including opportunistic infections. However, post-HCT infections remain a concern HCT recipients, particularly caused by community respiratory viruses (CRVs), which can lead significant morbidity mortality. These potentially cause lower tract illness, is associated with higher mortality rate among recipients. Clinical CRV includes supportive care antiviral therapy, especially high-risk individuals, when available. Directed therapy only available influenza infections, where successful use neuraminidase inhibitors (oseltamivir or zanamivir) and/or M2 (amantadine rimantadine) has been reported. Data on ribavirin, without immunomodulators, syncytial virus emerged but still controversial at best because lack randomized controlled trials. Because directed most these viruses, should be emphasized healthcare workers, patients, family, friends include promotion licensed inactivated vaccine indicated. In this review, we discuss special patient population, focusing commercially antivirals, adjuvant novel drugs under investigation, as well means prevention.

参考文章(132)
Margaret Okomo-Adhiambo, Ha T. Nguyen, Katrina Sleeman, Tiffany G. Sheu, Varough M. Deyde, Rebecca J. Garten, Xiyan Xu, Michael W. Shaw, Alexander I. Klimov, Larisa V. Gubareva, Host cell selection of influenza neuraminidase variants: Implications for drug resistance monitoring in A(H1N1) viruses Antiviral Research. ,vol. 85, pp. 381- 388 ,(2010) , 10.1016/J.ANTIVIRAL.2009.11.005
Angela J. Peck, Janet A. Englund, Jane Kuypers, Katherine A. Guthrie, Lawrence Corey, Rhoda Morrow, Robert C. Hackman, Anne Cent, Michael Boeckh, Respiratory virus infection among hematopoietic cell transplant recipients: evidence for asymptomatic parainfluenza virus infection. Blood. ,vol. 110, pp. 1681- 1688 ,(2007) , 10.1182/BLOOD-2006-12-060343
P Ljungman, G Avetisyan, Influenza vaccination in hematopoietic SCT recipients Bone Marrow Transplantation. ,vol. 42, pp. 637- 641 ,(2008) , 10.1038/BMT.2008.264
L Öhrmalm, A Lindblom, H Omar, O Norbeck, I Gustafson, I Lewensohn-Fuchs, J-E Johansson, M Brune, P Ljungman, K Broliden, Evaluation of a surveillance strategy for early detection of adenovirus by PCR of peripheral blood in hematopoietic SCT recipients: incidence and outcome Bone Marrow Transplantation. ,vol. 46, pp. 267- 272 ,(2011) , 10.1038/BMT.2010.86
Ted A. Gooley, Jason W. Chien, Steven A. Pergam, Sangeeta Hingorani, Mohamed L. Sorror, Michael Boeckh, Paul J. Martin, Brenda M. Sandmaier, Kieren A. Marr, Frederick R. Appelbaum, Rainer Storb, George B. McDonald, Reduced mortality after allogeneic hematopoietic-cell transplantation. The New England Journal of Medicine. ,vol. 363, pp. 2091- 2101 ,(2010) , 10.1056/NEJMOA1004383
S Chakrabarti, KE Collingham, CD Fegan, D Pillay, DW Milligan, Adenovirus infections following haematopoietic cell transplantation: is there a role for adoptive immunotherapy? Bone Marrow Transplantation. ,vol. 26, pp. 305- 307 ,(2000) , 10.1038/SJ.BMT.1702508
Larisa V Gubareva, A Angelica Trujillo, Margaret Okomo-Adhiambo, Vasiliy P Mishin, Varough M Deyde, Katrina Sleeman, Ha T Nguyen, Tiffany G Sheu, Rebecca J Garten, Michael W Shaw, Alicia M Fry, Alexander I Klimov, Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro Antiviral Therapy. ,vol. 15, pp. 1151- 1159 ,(2010) , 10.3851/IMP1678
Estella Whimbey, MD, Janet A. Englund, MD, Robert B. Couch, MD, Community respiratory virus infections in immunocompromised patients with cancer. The American Journal of Medicine. ,vol. 102, pp. 10- 18 ,(1997) , 10.1016/S0002-9343(97)80004-6
Frederick G. Hayden, Darrell T. Herrington, Teresa L. Coats, Kenneth Kim, Ellen C. Cooper, Stephen A. Villano, Siyu Liu, Spencer Hudson, Daniel C. Pevear, Marc Collett, Mark McKinlay, , Efficacy and Safety of Oral Pleconaril for Treatment of Colds Due to Picornaviruses in Adults: Results of 2 Double-Blind, Randomized, Placebo-Controlled Trials Clinical Infectious Diseases. ,vol. 36, pp. 1523- 1532 ,(2003) , 10.1086/375069
Lawrence Corey, Michael Boeckh, Benedetto Bruno, Theodore Gooley, Robert C Hackman, Chris Davis, Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival. Biology of Blood and Marrow Transplantation. ,vol. 9, pp. 341- 352 ,(2003) , 10.1016/S1083-8791(03)00102-2