Adenovirus infection in hematopoietic stem cell transplantation: effect of ganciclovir and impact on survival.

摘要: Adenoviruses (ADV) are emerging as important causes of morbidity and mortality in patients undergoing hematopoietic stem cell transplantation (HSCT). In mainly non-T-cell depleted HSCT recipients, we analyzed the incidence ADV infection, risk factors for effect ganciclovir administered prevention cytomegalovirus (CMV), impact infection on survival. The overall ADV, irrespective method detection, was 8.5% (450/5233) 12.3% (43/348) after first or second allogeneic HSCT, 6.3% (78/1219) 6.5% (5/77) autologous respectively. most frequent sites disease were stool gastrointestinal tract, Statistically significant associated with infections among recipients included younger age, grade II to IV graft-versus-host disease, year transplantation, a HSCT. Furthermore, seronegative CMV at seropositive who did not receive ganciclovir, either engraftment pre-emptive therapy reactivation, higher developing compared received (odds ratio=1.8, 95% confidence interval (CI) 1.2 2.8, P=.005 odds ratio=3.4, CI 2.1 5.55, P<.0001, respectively). hazard contracted those (hazard ratio 1.5, 1.3 1.7, P<.0001). This study shows that poor outcome T-cell repleted recipients. Ganciclovir, given prevention, may have protective effect. Controlled treatment studies warranted.