Impact of Ischemia-Reperfusion on Extracellular Matrix Processing and Structure of the Basement Membrane of the Heart
作者： Alexander Lauten , Alexandra Gerhard-Garcia , Frank Suhr , Juergen H. Fischer , Hans R. Figulla
DOI: 10.1371/JOURNAL.PONE.0092833
关键词: Liberation 、 Cell biology 、 Basement membrane 、 Angiogenesis 、 Tumstatin 、 Immunology 、 Ischemia 、 Chemistry 、 Reperfusion injury 、 Perlecan 、 Extracellular matrix 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Purpose Acute ischemic injury is a strong inductor of cardiac remodelling, resulting in structural changes the extracellular matrix (ECM) and basement membrane (BM). In large animal model ischemia-reperfusion (I/R) we investigated post-ischemic liberation collagen-IV-fragments Tumstatin (TUM; 28 kDa-fragment collagen-IV-alpha-3), Arresten (ARR; 26 collagen-IV-alpha-1) Endorepellin (LG3, 85 perlecan) which are biologically active angiogenesis vascularization myocardium.
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