Association between specific KRAS mutations and the clinicopathological characteristics of colorectal tumors
作者： HILMI KODAZ , ILHAN HACIBEKIROGLU , BULENT ERDOGAN , ESMA TURKMEN , HILMI TOZKIR
DOI: 10.3892/MCO.2014.448
关键词: KRAS Mutation Analysis 、 Point mutation 、 Oncogene 、 Colorectal cancer 、 Pathology 、 Cancer research 、 Metastasis 、 Medicine 、 KRAS 、 Primary tumor 、 Cancer
摘要: The aim of this study was to investigate the clinicopathological characteristics and distribution by tumor localization KRAS point mutations in metastatic colorectal cancer. A total 189 patients diagnosed with cancer between 2007 2014, who were either at time diagnosis or developed metastasis subsequently, included study. mutation analysis performed primary tissues identified 47.6% patients. There a high frequency p.G13D left-colon tumors (P=0.011), while p.G12D more frequent right-colon (P=0.004). wild-type (P=0.02) higher among aged 50-year-old group (P=0.03) codon 13 common <70-year-old (P=0.04). localized right colon (P=0.005) (P=0.018) non-metastatic stages. In conclusion, exhibited heterogeneous terms localization. addition, found differ from other several aspects.
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