Effects of iron loading on pathogenicity in hepatitis C virus-infected chimpanzees.

摘要: Elevated iron levels have been associated with raised serum alanine transaminase (ALT) in hepatitis C virus (HCV)-infected humans. However, it is not clear if HCV infection causes increased accumulation by the liver or severity of actually worsened higher host. To better understand relationship between and persistent infections, we examined effect excess dietary on disease HCV-infected chimpanzees. Iron was supplemented diets four two uninfected chimpanzees for 29 weeks to achieve loading. loading confirmed increases levels, percentages transferrin saturation, ferritin elevations hepatic concentration (HIC), histological examination. The majority had before feeding than animals. Although various degrees occurred all chimpanzees, animals exhibited comparison effects expression determined comparing parameters during an extended baseline period immediately following did influence viral load, but exacerbate injury as evidenced elevated ALT changes. Because high experienced loading, pathological were only observed appears increase susceptibility These results confirm extend previous observations made human populations serve further validate chimpanzee model chronic C.