Comparison of SHR, WKY and Wistar rats in different behavioural animal models: effect of dopamine D1 and alpha2 agonists
作者： Barbara Langen , Rita Dost
DOI: 10.1007/S12402-010-0034-Y
关键词: Novel object recognition 、 Guanfacine 、 Agonist 、 Quinpirole 、 Open field 、 Dopamine 、 Internal medicine 、 Elevated plus maze 、 Psychology 、 Endocrinology 、 Amphetamine 、 Clinical psychology 、 Psychiatry and Mental health 、 General Medicine
摘要: Spontaneously hypertensive rats (SHR) and its counterpart, the Wistar-Kyoto (WKY), are probably most often used animal model of ADHD. However, SHR as ADHD have also been criticised partly because not differing to outbred rat strains. In present study, adolescent SHR, WKY Wistar from Charles River were tested in open-field, elevated plus maze novel object recognition on gastrointestinal transport more intensively evaluate strain characteristics. Non-habituated active than but contrary stay hyperactive a familiar environment. sensitive alpha2-adrenoceptor agonist guanfacine dopamine D1 A-68930 rats, whereas amphetamine, D1/D5 ABT431 D2 quinpirole, similarly affected open-field activity all maze, showed less anxiety-related behaviour rats. Guanfacine amphetamine induced an anxiolytic-like highest long-term memory recognition. Gastrointestinal was similar comparably by The study shows clear differences use is supported.
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