A truncated form of the IRF-2 transcription factor has the properties of a postinduction repressor of interferon-beta gene expression.
作者： S T Whiteside , P King , S Goodbourn
DOI: 10.1016/S0021-9258(18)47125-6
关键词: Repressor 、 Transcription (biology) 、 Response element 、 Gene expression 、 Transcription factor 、 Biology 、 Molecular biology 、 General transcription factor 、 Binding protein 、 Regulatory sequence
摘要: The interferon-beta promoter binding protein, IRF-2, is proteolytically processed during induction by double-stranded RNA to leave an N-terminal fragment that can still bind DNA. An corresponds the induction-specific product has a higher affinity for and more potent repressor of transcription than full-length precursor. kinetics production cleavage slower activation transcription. These results suggest IRF-2 functions generate postinduction expression.
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