Aneuploidy and Confined Chromosomal Mosaicism in the Developing Human Brain

作者: Yuri B. Yurov , Ivan Y. Iourov , Svetlana G. Vorsanova , Thomas Liehr , Alexei D. Kolotii

DOI: 10.1371/JOURNAL.PONE.0000558

关键词: KaryotypeChromosomeChromosome instabilityHuman brainGeneticsAneuploidyBiologyStructural variationPloidyGenomeGeneral Biochemistry, Genetics and Molecular BiologyGeneral Agricultural and Biological SciencesGeneral Medicine

摘要: Background Understanding the mechanisms underlying generation of neuronal variability and complexity remains the central challenge for neuroscience. Structural variation in the …

参考文章(30)
Terry Hassold, Patricia Hunt, To err (meiotically) is human: the genesis of human aneuploidy Nature Reviews Genetics. ,vol. 2, pp. 280- 291 ,(2001) , 10.1038/35066065
Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Genetic instabilities in human cancers Nature. ,vol. 396, pp. 643- 649 ,(1998) , 10.1038/25292
Ivan Y. Iourov, Svetlana G. Vorsanova, Yuri B. Yurov, Chromosomal variation in mammalian neuronal cells: known facts and attractive hypotheses. International Review of Cytology-a Survey of Cell Biology. ,vol. 249, pp. 143- 191 ,(2006) , 10.1016/S0074-7696(06)49003-3
Paul Smaglik, Taking a break can lend focus Nature. ,vol. 441, pp. 903- 903 ,(2006) , 10.1038/NJ7095-903A
Yan Yang, David S. Geldmacher, Karl Herrup, DNA Replication Precedes Neuronal Cell Death in Alzheimer's Disease The Journal of Neuroscience. ,vol. 21, pp. 2661- 2668 ,(2001) , 10.1523/JNEUROSCI.21-08-02661.2001
D. H. Ly, Mitotic misregulation and human aging. Science. ,vol. 287, pp. 2486- 2492 ,(2000) , 10.1126/SCIENCE.287.5462.2486
Kei Watase, Huda Y. Zoghbi, Modelling brain diseases in mice: the challenges of design and analysis Nature Reviews Genetics. ,vol. 4, pp. 296- 307 ,(2003) , 10.1038/NRG1045
S. K. Rehen, M. J. McConnell, D. Kaushal, M. A. Kingsbury, A. H. Yang, J. Chun, Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 13361- 13366 ,(2001) , 10.1073/PNAS.231487398
M. A. Kingsbury, B. Friedman, M. J. McConnell, S. K. Rehen, A. H. Yang, D. Kaushal, J. Chun, Aneuploid neurons are functionally active and integrated into brain circuitry. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 6143- 6147 ,(2005) , 10.1073/PNAS.0408171102
Harith Rajagopalan, Christoph Lengauer, Aneuploidy and cancer Nature. ,vol. 432, pp. 338- 341 ,(2004) , 10.1038/NATURE03099