Adenosine Deaminase Activity in Lymphoid Subpopulations and Leukemias
作者： A Stanton , B H Davis , H Simpkins
DOI:
关键词: Lysis 、 Specific activity 、 Sezary Cell 、 Molecular biology 、 Biology 、 Enzyme 、 Adenosine deaminase 、 Lymphoblast 、 Leukemia 、 Immunology 、 Cell
摘要: Adenosine deaminase has been measured by the indirect spectrophotometric method in lymphoblasts from adult and pediatric lymphoblastic leukemias, peripheral T- B-cells, mature T-cell leukemia (Sezary cell), mitogen-stimulated control B-cells. It was found that, if specific activity of enzyme is expressed terms cell cytoplasmic protein concentration rather than number, null-cell levels markedly higher leukemic or Sezary cells. The range values far less those reported other authors using direct assay number prior to lysis. Non-leukemic B-cells individuals show minor differences as do T gamma-enriched Lymphocytes female oriental populations were significantly lower. Both lymphocytes similar elevations adenosine so that no effect per se can be ascribed transformation.
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