In vivo Neural Crest Cell Migration Is Controlled by "Mixotaxis".

摘要: Directed cell migration is essential all along an individual's life, from embryogenesis to tissue repair and cancer metastasis. Thus, due its biomedical relevance, directed currently under intense research. has been shown be driven by assortment of external biasing cues, ranging gradients soluble (chemotaxis) bound (haptotaxis) molecules. In addition molecular gradients, mechanical properties (duro/mechanotaxis), electric fields (electro/galvanotaxis) as well iterative biases in the environment topology (ratchetaxis) have able direct migration. Since cells migrating vivo are exposed a challenging composed convolution biochemical, biophysical, topological it highly unlikely that would guided individual type "taxis." This especially true since numerous players involved cellular response these cues often recycled, serving sensor or transducer both biochemical biophysical signals. this review, we confront literature on Xenopus cephalic neural crest with other types discuss relevance current categorization guidance strategies. Furthermore, emphasize while studying signals informative, hard truth migrate performing sort "mixotaxis," where they integrate coordinate multiple inputs through shared effectors ensure robustness motion.