Higher notch expression implies poor survival in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis.

摘要: Abstract Background At present, pancreatic ductal adenocarcinoma (PDAC) is a fetal disease lack of effective prognostic and therapeutic methods resulting in high mortality. The Notch signaling has been demonstrated being up- or down-regulated many cancers, but the effects are still controversial. Moreover, available cases an individual study small samples. Therefore, it essential to define effect with larger Methods Conducted from 6 eligible studies 463 patients, this was first meta-analysis analyze correlation between signal pathway adenocarcinoma. All data were sourced National Center for Biotechnology Information, Web Science Cochrane. articles which matched inclusion criteria included. included analyzed performed by Review Manager 5.3. Results results indicated that expression proteins associated poor overall survival patients (pooled hazard ratio>2.00; P  Conclusions This supports may be as factors progression patient survival. Higher patients. Targeting components, especially Notch3 protein, would beneficial therapies.