Urokinase plasminogen activator: a prognostic marker in multiple types of cancer.

摘要: Urokinase plasminogen activator (uPA) is a serine protease causally involved in cancer invasion and metastasis. Consistent with its role spread, uPA has been shown to be prognostic marker variety of malignancies, especially breast cancer. Approximately 20 different groups have that high levels tumor tissue predict poor outcome. As cancer, provides information independent traditionally used factors such as size, grade, axillary node status estrogen receptor status. Furthermore, node-negative patients, clinical trial currently under way assess whether inhibitor, inhibitor-1, can differentiate between the majority patients who are cured by surgery from minority might benefit adjuvant therapy. also other gastric, colorectal, esophageal, renal, endometrial, ovarian cancers. may thus indicator for multiple types adenocarcinoma.