Risperidone-Loaded Mucoadhesive Microemulsion for Intranasal Delivery: Formulation Development, Physicochemical Characterization and Ex Vivo Evaluation
作者： RB Patel , MR Patel , KK Bhatt , BG Patel , None
DOI: 10.1016/S1773-2247(13)50085-2
关键词: Nasal administration 、 Microemulsion 、 Oleic acid 、 Dispersity 、 Drug delivery 、 Pulmonary surfactant 、 Chemistry 、 Chromatography 、 Aqueous solution 、 Ex vivo
摘要: This paper describes the formulation development, physicochemical characterization and ex vivo evaluation of a microemulsion drug delivery system designed for intranasal administration risperidone. Drug-loaded microemulsions which contained 4 % oleic acid, 30 surfactant mixture [Labrasol: Cremophor RH 40 (1:1)]:[Transcutol P] (3:1) 66 (w/w) aqueous were successfully prepared by water titration method. The displayed an optical transparency 99.96 %, globule size 21.08 ± 1.35 nm, polydispersity index 0.109 ± 0.017 was selected incorporation polyelectrolytic polymer (polycarbophil) as mucoadhesive component. risperidone containing 0.5 w/w polycarbophil showed higher in vitro potential (17.0 ± 1.5 min) diffusion coefficient (3.72 × 10-6 ± 0.022 × 10 - 6 ) compared to microemulsion. All formulations found be free from nasal cilio toxicity stable six months.
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