Expression and Activity of 25-Hydroxyvitamin D-1α-Hydroxylase Are Restricted in Cultures of Human Syncytiotrophoblast Cells from Preeclamptic Pregnancies
作者： Lorenza Díaz , Celeste Arranz , Euclides Avila , Ali Halhali , Felipe Vilchis
关键词: Calcitriol receptor 、 Gene expression 、 25-Hydroxyvitamin D3 1-alpha-hydroxylase 、 Biology 、 Placenta 、 Internal medicine 、 Calcium metabolism 、 Preeclampsia 、 Syncytiotrophoblast 、 Messenger RNA 、 Endocrinology
摘要: The human placenta synthesizes 1,25-dihydroxyvitamin D3 and expresses the vitamin D receptor. Because preeclampsia (PE) is associated with low circulating levels of maternal IGF-I, it possible that alterations in calcium metabolism seen PE could occur at level fetoplacental unit. In this study, patterns gene expression enzyme activity 25-hydroxyvitamin d-1α-hydroxylase (1α-hydroxylase) abundance IGF-I mRNA placentas from normal (NT) PE-complicated pregnancies were investigated. Cultured syncytiotrophoblast cells preeclamptic had only one tenth 1α-hydroxylase did not respond to when compared NT cultures. Similarly, under basal IGF-I-stimulated conditions significantly reduced. contrast, found increase during differentiation process, no differences between NT...
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