HLA-DR3 associated genetic control of response to multiple skin tests with new tuberculins.

摘要: Multiple skin testing with mycobacterial antigenic preparations reveals distinct reaction patterns, which might be relevant to the development of disease in man. Previous work has shown that HLA-DR associated factors correlate position a leprosy patient immunopathological spectrum leprosy. This study was undertaken see whether these test patterns healthy persons do show any association types. Out group 74 Caucasoid individuals HLA-DR3 observed absent from 16 who did not respond antigens tested. is striking difference distribution both among 17 responded all tested (P = 0.005) and 41 some but 0.015). These data an genetic factor controls, albeit indirectly, responsiveness antigens. It may significant this same determinant implicated deciding type developed by patient.