Muscarinic-activated K+ current in bovine aortic endothelial cells.
作者： S P Olesen , P F Davies , D E Clapham
关键词: Muscarinic acetylcholine receptor 、 Atropine 、 Acetylcholine 、 Stimulation 、 Inward-rectifier potassium ion channel 、 Cholinergic 、 Biology 、 Endothelium 、 Endocrinology 、 Hyperpolarization (biology) 、 Internal medicine
摘要: Isolated, cultured arterial endothelial cells express an acetylcholine (ACh)-activated K+ current in addition to inward rectifier whose conductance is unaffected by ACh. The cholinergic specifically blocked atropine (1 microM) and shows single saturation kinetics with ACh (half-maximal stimulation 51 nM ACh). Unlike the cardiac muscarinic receptor-gated channel, its appears independent of a pertussis toxin-sensitive GTP-binding protein. Activation resulting hyperpolarization may represent initial component vasodilatory effect
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