Targeted costimulatory polypeptides and methods of use to treat cancer
作者： Solomon Langermann
DOI:
关键词: Molecular biology 、 Fusion protein 、 Biology 、 Binding domain 、 Peptide 、 Immune system 、 Cell biology 、 T cell 、 Function (biology) 、 Cancer 、 Linker
摘要: Compositions are provided that targeted to tumors or tumor- associated neovasculature and enhance the function of tumor-infiltrating T cells. The compositions include fusion proteins contain a cell binding domain tumor/tumor-associated targeting domain. optionally peptide/polypeptide linker mediates dimerization multimerization. can be costimulatory molecule. Methods for using an immune response provided. Therapeutic uses disclosed induction tumor immunity.
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