Advances in Research in Animal Models of Burn-Related Hypertrophic Scarring

摘要: Skin burn injuries affect approximately 500,000 people per year in France. After deep burns, functional sequelae associated with hypertrophic and retractile scars are an important public health problem. To understand the pathophysiology of evaluate new therapeutic approaches, use animal models that should be standard tools is necessary. Some pre-clinical after burns have been described, but choice appropriate relevant experimental model crucial to accurately investigate any approach. A variety scar described lesions; none which being totally satisfactory. The most frequently used skin excision ear rabbit, this does not reflect injuries. red Duroc pig seems more human scarring burns; however, because costs lack studies evaluating species, domestic commonly research. Elevated obtained, they spontaneously resolve within a year. Although mortality small animals higher creates technical difficulties, many on nude mice Indeed, transplantation tissue or grafts may induce can last than permitting additional manipulation experimentation.