Physiological Monitoring in Deep Brain Stimulation: Toward Closed-Loop Neuromodulation Therapies

摘要: Deep brain stimulation (DBS) is a widely used, efficacious neurosurgical treatment for neurological movement disorders. For example, electrical in the ventral intermediate thalamic nucleus drastically reduces tremor patients with essential tremor. Likewise, subthalamic or internal globus pallidus significantly attenuates tremor, rigidity, bradykinesia, and gait complications of Parkinson’s disease. Its application now rapidly expanding to wide variety conditions including epilepsy, neuropsychiatric disorders, Tourette syndrome, Alzheimer’s disease, intractable pain. However, exact underlying therapeutic mechanisms action DBS remain unclear. Despite this lack understanding, clinical utility cannot be underappreciated, there great need studies that can elucidate patient-specific optimization parameters targets. This chapter explores recent approaches studying DBS. Additionally, it discusses limitations current open-loop accentuates importance developing smart closed-loop system optimize real time individual symptoms.