Increased Glioma Growth in Mice Depleted of Macrophages

摘要: Macrophages can promote the growth of some tumors, such as those breast and lung, but it is unknown whether this true for all including nervous system. On contrary, we have previously shown that macrophages slow progression malignant gliomas through a tumor necrosis factor-dependent mechanism. Here, provide evidence suggesting antitumor effect could be mediated by T lymphocytes, their number was drastically reduced in factor-deficient mice inversely correlated with glioma volume. However, correlation only observed allogeneic recipients, prompting reevaluation role nonimmunogenic context. Using syngeneic expressing herpes simplex virus thymidine kinase under control CD11b promoter, show exert an without help lymphocytes. Macrophage depletion achieved ganciclovir treatment resulted 33% increase The not likely due to tumoricidal activity because phagocytosis or apoptosis cells, transduced ex vivo lentiviral vector green fluorescent protein, rarely observed. Their also destructive action on vasculature macrophage modest reduction vascular density. Therefore, study suggests attenuate unconventional This validates new transgenic model explore cancer.