Age-Related Morphologic Alterations in the Brain of Old World and New World Anthropoid Monkeys

摘要: Anthropoid monkeys are subdivided into two large groups, the New World platyrrhine (callithricids and cebids) Old catarrhine (macaques, baboons, guenons, leaf-eating monkeys). Most taxa poorly known from a neurobiological point of view, but many species used for laboratory studies (in particular, some macaques baboons [Macaca Papio], Patas monkey [Erythrocebus], Central South American marmoset [Callthrix], owl [Aotus], squirrel [Saimiri], capuchin [Cebus] Aging is particularly well documented among these long-tailed rhesus monkey. The basis declining cortical function in primate aging remains to be defined. One possibility that structural integrity neocortex compromised by frank neuronal degeneration, synaptic loss, or other morphologic alterations. consensus emerging recent studies, however, areas, including subdivisions hippocampal, prefrontal, motor, sensory cortices participate critically integration memory-related processes, relatively resistant cell death during normal monkeys. In contrast, subcortical structures more consistently affected manner correlates with severity cognitive deficits. Importantly, ultrastructural cellular analyses have demonstrated subtle alterations involving neuropil as restricted domains dendritic trees likely contribute massively, together molecular changes specific neurotransmitter receptor proteins, memory deficits observed aged anthropoid