Expression analysis of genes involved in collagen cross-linking and its regulation in traumatic anterior shoulder instability.

作者: Paulo Santoro Belangero , Mariana Ferreira Leal , Carina Cohen , Eduardo Antônio Figueiredo , Marília Cardoso Smith

DOI: 10.1002/JOR.22984

关键词: PathologyMatrix (biology)Downregulation and upregulationCollagen cross linkingGeneReceptorMedicineGene expressionAnterior shoulderCapsule

摘要: The molecular alterations involved in the capsule deformation presented shoulder instability patients are poorly understood. Increased TGFβ1 acts as a signal for production of matrix macromolecules by fibrogenic cells at joint injury sites. TGFβ1, through its receptor TGFβR1, regulates genes collagen cross-linking, such LOX, PLOD1, and PLOD2. We evaluated PLOD2 gene expression antero-inferior (macroscopically injured region), antero-superior posterior regions glenohumeral 29 eight controls. observed that was increased anterior-inferior region compared to LOX tended be portion patients. Patients with recurrent dislocation upregulation TGFβR1 region. Conversely, single episode. In antero-inferior, inversely correlated directly duration symptoms. region, PLOD2, were conclusion, macroscopically Upregulation seems related maintenance disease symptoms, especially occur only initial phase affection. Therefore, may play role instability. © 2015 Orthopaedic Research Society. Published Wiley Periodicals, Inc. J Orthop Res 34:510–517, 2016.

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