Islet transplantation to the renal subcapsular space in streptozotocin-diabetic rats: short-term effects on glucose-stimulated insulin secretion.
作者： Aamer Ar Rajab , Bo Ahrén , Stig Bengmark
DOI: 10.1016/0168-8227(89)90005-3
关键词: Insulin 、 Basal (medicine) 、 Medicine 、 Insulin secretion 、 Islet 、 Diabetes mellitus 、 Internal medicine 、 In vivo 、 Streptozotocin 、 Transplantation 、 Endocrinology
摘要: The immediate and short-term effects of transplantation freshly isolated islets on glucose-stimulated insulin secretion were studied in streptozotocin-diabetic rats. At 2 days after the intravenous injection streptozotocin (70 mg/kg), either 400 or 1000 isolated, hand-picked transplanted to left renal subcapsular space. Intravenous glucose infusion (10 mg/min) performed 1, 3, 6, 10 revealed that already at day rats with had a significant plasma response glucose, though was lower than healthy controls. 6 transplantation, islet-transplanted group near-normal glucose. Basal levels were, however, still slightly elevated. Rats those islets. It is concluded vivo secretory obtained space However, slight hyperglycemia persists.
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