Effects of yohimbine and nicotinic acid on insulin secretion in islet transplanted streptozotocin-diabetic rats

摘要: Abstract Whether insulin secretion from transplanted islets is normally regulated has not been established. We have studied the effects of either α-adrenoceptor antagonism or induction resistance on glucose-stimulated in streptozotocin (70 mg/kg)-diabetic rats with 1000 freshly isolated to left kidney subcapsular space. The α 2 -adrenoceptor antagonist yohimbine (15 μg/min) increased basal and potentiated control rats. In contrast, did affect This suggests that islet tonus lost following transplantation. Induction by nicotinic acid (6 mg orally twice daily for 10 days) was followed levels without any effect plasma glucose levels, both rats, as an adaptation resistance. Furthermore, after acid, response during infusion adequate maintain normal hyperglycemic response, controls retain capability adapt