Association of the fatty acid profile of serum lipids with glucose and insulin metabolism during 2 fat-modified diets in subjects with impaired glucose tolerance

摘要: BACKGROUND Both the amount and quality of dietary fat can modify glucose insulin metabolism. OBJECTIVE The objective was to examine relation between serum lipid fatty acids metabolism before after consumption a diet enriched in either monounsaturated (Mono diet) or polyunsaturated (Poly acids. DESIGN After consuming high-saturated-fat run-in for 3 wk, 31 subjects with impaired tolerance were randomly counseled consume Mono [40% fat; 11%, 19%, 8% energy as saturated, monounsaturated, (S:M:P), respectively] Poly (34% S:M:P 11%:10%:10%) 8 wk. Serum measured, an intravenous-glucose-tolerance test performed at baseline RESULTS At baseline, higher effectiveness (S(G)) associated proportions oleic (r = 0.57, P 0.04) alpha-linolenic 0.64, 0.01) phospholipids. An increase phospholipids decrease fasting plasma [r -0.53 (P 0.002) r -0.47 0.009), respectively]. S(G) proportion acid 0.55, 0.004) that arachidonic -0.40, CONCLUSIONS beneficial changes during alterations oleic, alpha-linolenic,