Stable micelles formed through a stereocomplex of amphiphilic copolymers zwitterionic-(PLLA)2 and MPEG-(PDLA)2 for controlled drug delivery
作者： Shasha Zhao , Xiaoshan Fan , Xiaoyan Li , Xianglin Lv , Weiwei Zhang
DOI: 10.1039/C6RA10825C
关键词: Critical micelle concentration 、 Zeta potential 、 Gel permeation chromatography 、 Micelle 、 Copolymer 、 Chemical engineering 、 Differential scanning calorimetry 、 Dynamic light scattering 、 Static light scattering 、 Polymer chemistry 、 Materials science
摘要: Y-Shaped amphiphilic copolymers (zwitterionic-(PLLA2.5K)2 and MPEG-(PDLA2.5K)2) were simply synthesized through click reaction of alkyne-(PLA2.5K)2 zwittterionic-N3 or MPEG-N3. Gel permeation chromatography (GPC) 1H nuclear magnetic resonance (1H NMR) employed to characterize the composition structure these copolymers. The stereocomplexes prepared from pairs zwitterionic-(PLLA2.5K)2/MPEG-(PDLA2.5K)2 (molar ratio = 1 : 1), confirmed by differential scanning calorimeter (DSC). Furthermore aggregation behaviors for polymers their had been proved fluorescence spectroscopy (PL), transmission electron microscopy (TEM), dynamic light scattering (DLS) static (SLS), zeta potential. Their critical micelle concentration (CMC) obtained PL was 0.0213 mg mL−1 zwitterionic-(PLLA2.5K)2/MPEG1.9K-(PDLA2.5K)2 0.1265 zwitterionic-(PLLA2.5K)2/MPEG5K-(PDLA2.5K)2. could self-assemble into spherical micelles with diameters 76 nm (zwitterionic-(PLLA2.5K)2/MPEG1.9K-(PDLA2.5K)2) 89 (zwitterionic-(PLLA2.5K)2/MPEG5K-(PDLA2.5K)2) respectively. biocompatibility evaluated relatively low cytotoxicity. DOX-loaded a higher drug loading content encapsulation efficiency, release DOX in controlled manner. Therefore, new stereocomplex zwitterionic-(PLLA)2/MPEG-(PDLA)2 has great potential as hydrophobic nanocarrier.
rsc.org
sci-hub.se 参考文章(41)
Zujiang Xiong, Xiuqin Zhang, Rui Wang, Sicco de Vos, Ruyin Wang, Cornelis A.P. Joziasse, Dujin Wang, Favorable formation of stereocomplex crystals in poly(L-lactide)/ poly(D-lactide) blends by selective nucleation Polymer. ,vol. 76, pp. 98- 104 ,(2015) , 10.1016/J.POLYMER.2015.08.056
Jia Yao, Huan Wu, Yuelei Ruan, Jun Guan, Annan Wang, Haoran Li, “Reservoir” and “barrier” effects of ABC block copolymer micelle in hydroxyapatite mineralization control Polymer. ,vol. 52, pp. 793- 803 ,(2011) , 10.1016/J.POLYMER.2010.12.017
Weiwei Zhang, Weiwei Jiang, Delong Zhang, Guangyue Bai, Pengxiao Lou, Zhiguo Hu, Synthesis, characterization and association behavior of linear-dendritic amphiphilic diblock copolymers based on poly(ethylene oxide) and a dendron derived from 2,2′-bis(hydroxymethyl)propionic acid Polymer Chemistry. ,vol. 6, pp. 2274- 2282 ,(2015) , 10.1039/C4PY01385A
Liu Yang, Zhenxian Zhao, Jia Wei, Abdelslam El Ghzaoui, Suming Li, Micelles formed by self-assembling of polylactide/poly(ethylene glycol) block copolymers in aqueous solutions Journal of Colloid and Interface Science. ,vol. 314, pp. 470- 477 ,(2007) , 10.1016/J.JCIS.2007.05.074
Shuying Zhai, Yuhao Ma, Yingying Chen, Dan Li, Jun Cao, Yanjun Liu, Mengtan Cai, Xiaoxiong Xie, Yuanwei Chen, Xianglin Luo, None, Synthesis of an amphiphilic block copolymer containing zwitterionic sulfobetaine as a novel pH-sensitive drug carrier Polymer Chemistry. ,vol. 5, pp. 1285- 1297 ,(2014) , 10.1039/C3PY01325A
Jinlong Yang, Chunmei Gao, Shaoyu Lü, Xinggang Wang, Mingjia Chen, Mingzhu Liu, Novel self-assembled amphiphilic mPEGylated starch-deoxycholic acid polymeric micelles with pH-response for anticancer drug delivery RSC Advances. ,vol. 4, pp. 55139- 55149 ,(2014) , 10.1039/C4RA07315K
Alice W Du, Hongxu Lu, Martina H Stenzel, None, Core-Cross-Linking Accelerates Antitumor Activities of Paclitaxel-Conjugate Micelles to Prostate Multicellular Tumor Spheroids: A Comparison of 2D and 3D Models Biomacromolecules. ,vol. 16, pp. 1470- 1479 ,(2015) , 10.1021/ACS.BIOMAC.5B00282
Marina A. Dobrovolskaia, Parag Aggarwal, Jennifer B. Hall, Scott E. McNeil, Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Molecular Pharmaceutics. ,vol. 5, pp. 487- 495 ,(2008) , 10.1021/MP800032F
Jun Cao, Aijing Lu, Chenglong Li, Mengtan Cai, Yuanwei Chen, Sai Li, Xianglin Luo, None, Effect of architecture on the micellar properties of poly (ɛ-caprolactone) containing sulfobetaines. Colloids and Surfaces B: Biointerfaces. ,vol. 112, pp. 35- 41 ,(2013) , 10.1016/J.COLSURFB.2013.07.038
Lianwei Li, Chen He, Weidong He, Chi Wu, Formation Kinetics and Scaling of ``Defect-Free'' Hyperbranched Polystyrene Chains with Uniform Subchains Prepared from Seesaw-Type Macromonomers Macromolecules. ,vol. 44, pp. 8195- 8206 ,(2011) , 10.1021/MA201687S