Core-Cross-Linking Accelerates Antitumor Activities of Paclitaxel-Conjugate Micelles to Prostate Multicellular Tumor Spheroids: A Comparison of 2D and 3D Models
作者： Alice W Du , Hongxu Lu , Martina H Stenzel , None
DOI: 10.1021/ACS.BIOMAC.5B00282
关键词:
摘要: The 2D monolayer cell culture model is often the first step in prediction of success or failure a nanoparticle-based drug delivery system. However, there poor translation between vitro results and nanoparticle–drug performance vivo. One possible way bridging this gap use multicellular tumor spheroids (MCTSs) as an intermediate due to its 3D structure. This paper aims quantify compare obtained from traditional cultures MCTS by studying cytotoxic effects free paclitaxel (PTX) paclitaxel, which has been conjugated poly(ethylene glycol methyl ether acrylate)-b-poly(carboxyethyl acrylate) (POEGMEA-b-PCEA-PTX) block copolymer self-assembled give micellar core micelle was cross-linked with diamino nondegradable cross-linker stability on results. Although prostate indicat...
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