Complete sets of monosubstituted cyclomaltohexaoses (α-cyclodextrins) as precursors for further synthesis.
作者： Michal Řezanka , Jindřich Jindřich
DOI: 10.1016/J.CARRES.2011.08.011
关键词: Proton NMR 、 Bromide 、 Organic chemistry 、 Ozonolysis 、 Chemistry 、 Alkylation 、 Oxidative cleavage
摘要: Abstract Alkylation of cyclomaltohexaose (α-cyclodextrin, α-CD) with allyl or cinnamyl bromide, followed by peracetylation remaining hydroxyl groups and separation isomers, resulted in the set peracetylated 2 I -O-, 3 -O- 6 -O-alkylated α-CDs up to 27% yields. Ozonolysis oxidative cleavage derivatives a complete - O , -O -formylmethyl carboxymethyl that are useful precursors for preparation regioselectively monosubstituted α-CD. Moreover, quick method recognize single -O-monosubstituted CDs from one another using only their 1 H NMR spectra has been proposed.
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