The study of enantioselectivity of all regioisomers of mono‐carboxymethyl‐β‐cyclodextrin used as chiral selectors in CE

摘要: This work documents the influence of position single carboxymethyl group on β-cyclodextrin skeleton enantioselectivity. These synthesized monosubstituted cyclodextrin (CD) derivatives, native β-cyclodextrin, and commercially available carboxymethyl-β-cyclodextrin with degree substitution approximately 3 were used as additives into BGE consisting phosphate buffer at 20 mmol/L concentration, pH 2.5, several biologically significant low-molecular-mass chiral compounds enantioseparated by CE. The results indicate that different substituent location has a enantioseparation investigated enantiomers. enantioselectivity 2(I)-O-regioisomer was better than β-cyclodextrin. Comparable to obtained for 6(I)-O- regioisomer 3(I)-O-regioisomer even worse Commercially derivative CD provides resolutions derivatives most analytes.