The influence of the substituent position in monocarboxymethyl‐γ‐cyclodextrins on enantioselectivity in capillary electrophoresis

摘要: Three newly synthesized chiral selectors, namely, 2I-O-, 3I-O-, and 6I-O-carboxymethyl-γ-cyclodextrin, native γ-cyclodextrin, commercially available carboxymethylated γ-cyclodextrin with degree of substitution 3–6 were used as additives in a background electrolyte composed phosphate buffer at 20 mmol/L concentration pH 2.5. This system was for the analysis several biologically significant low-molecular-mass compounds by capillary electrophoresis. The results confirmed that position carboxymethyl group influences enantioseparation efficiency all studied analytes. 2I-O- 3I-O- regioisomers provide significantly better resolution than while 6I-O-regioisomer gives only slightly γ-cyclodextrin. application possessing higher number groups led to best majority analyzed.