The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription
作者： Ramsey I Cutress , Paul A Townsend , Adam Sharp , Anna Maison , Lynn Wood
关键词: Nuclear localization sequence 、 Endocrinology 、 Cell biology 、 Cell nucleus 、 Estrogen receptor alpha 、 Progesterone receptor 、 Receptor 、 Nuclear receptor 、 Gene isoform 、 Biology 、 Cancer 、 Internal medicine
摘要: BAG-1 is a multifunctional protein that interacts with wide range of cellular targets including heat-shock proteins and some nuclear hormone receptors. exists as three major isoforms, BAG-1L, BAG-1M BAG-1S. BAG-1L contains localization signal, which not present in the other predominantly localized cell nucleus. Here we have investigated effects on function oestrogen receptor (ER), key growth control molecule target for hormonal therapy breast cancer. We demonstrate but BAG-1S or BAG-1M, increased oestrogen-dependent transcription cancer cells. interacted stimulated activity both ER alpha beta. Although ERs colocalize to nucleus, fusing an heterologous sequence was sufficient stimulate transcription. Consistent important effect function, expression cancers associated progesterone receptor, transcriptional ERalpha, improved survival patients treated therapy. These data suggest determinant vitro human
nature.com
core.ac.uk
manchester.ac.uk参考文章(37)
S. Mandlekar, A.-N. T. Kong, Mechanisms of tamoxifen-induced apoptosis. Apoptosis. ,vol. 6, pp. 469- 477 ,(2001) , 10.1023/A:1012437607881
H J G Bloom, W W Richardson, Histological grading and prognosis in breast cancer; a study of 1409 cases of which 359 have been followed for 15 years. British Journal of Cancer. ,vol. 11, pp. 359- 377 ,(1957) , 10.1038/BJC.1957.43
Paul Pace, Jacqueline Taylor, Sumathy Suntharalingam, R. Charles Coombes, Simak Ali, Human estrogen receptor beta binds DNA in a manner similar to and dimerizes with estrogen receptor alpha. Journal of Biological Chemistry. ,vol. 272, pp. 25832- 25838 ,(1997) , 10.1074/JBC.272.41.25832
David Dickson, Paul Smaglik, UK government backs change in law over stem-cell research.. Nature. ,vol. 406, pp. 815- ,(2000) , 10.1038/35022712
Klára Briknarová, Shinichi Takayama, Lars Brive, Marnie L. Havert, Deborah A. Knee, Jesus Velasco, Sachiko Homma, Edelmira Cabezas, Joan Stuart, David W. Hoyt, Arnold C. Satterthwait, Miguel Llinás, John C. Reed, Kathryn R. Ely, Structural analysis of BAG1 cochaperone and its interactions with Hsc70 heat shock protein. Nature Structural & Molecular Biology. ,vol. 8, pp. 349- 352 ,(2001) , 10.1038/86236
Tamoxifen for early breast cancer: An overview of the randomised trials The Lancet. ,vol. 351, pp. 1451- 1467 ,(1998) , 10.1016/S0140-6736(97)11423-4
A. Bardelli, P. Longati, D. Albero, S. Goruppi, C. Schneider, C. Ponzetto, P. M. Comoglio, HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. The EMBO Journal. ,vol. 15, pp. 6205- 6212 ,(1996) , 10.1002/J.1460-2075.1996.TB01009.X
Xiaolong Yang, Zhihu Ding, Yawei Hao, Alan Pater, Shou Ching Tang, Differential Expression of Antiapoptotic Gene BAG-1 in Human Breast Normal and Cancer Cell Lines and Tissues Clinical Cancer Research. ,vol. 5, pp. 1816- 1822 ,(1999)
R. I. Cutress, P. A. Townsend, A. C. Bateman, P.W.M. Johnson, K. Ryder, D. M. Barnes, G. Packham, Bruce C. Turner, John C. Reed, BAG-1 immunostaining and survival in early breast cancer Journal of Clinical Oncology. ,vol. 19, pp. 3706- 3707 ,(2001) , 10.1200/JCO.2001.19.16.3706
M. Zeiner, Y. Niyaz, U. Gehring, The hsp70-associating protein Hap46 binds to DNA and stimulates transcription Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 10194- 10199 ,(1999) , 10.1073/PNAS.96.18.10194