Anti-colchicine Fab fragments prevent lethal colchicine toxicity in a porcine model: a pharmacokinetic and clinical study
作者： Michael Eddleston , Nicolas Fabresse , Adrian Thompson , Ibrahim Al Abdulla , Rachael Gregson
DOI: 10.1080/15563650.2017.1422510
关键词: Clinical study 、 Toxicity 、 Fab Fragments 、 Antidote 、 Colchicine 、 Pharmacology 、 Colchicine poisoning 、 Urinary system 、 Medicine 、 Pharmacokinetics
摘要: Background: Colchicine poisoning is commonly lethal. Colchicine-specific Fab fragments increase rat urinary colchicine clearance and have been associated with a good outcome in one patient. We aime...
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M. Urtizberea, A. Sabouraud, M. Lachaise, O. Chappey, V. Cosson, F. J. Baud, J. M. Scherrmann, Pharmacokinetics of total and free digoxin and Fab fragments in 5 intoxicated patients after administration of specific anti-digoxin Fab fragments. Archives of Toxicology. ,vol. 14, pp. 132- 135 ,(1991) , 10.1007/978-3-642-74936-0_26
Bin Wu, Ting Xu, Youping Li, Xi Yin, Interventions for reducing inflammation in familial Mediterranean fever Cochrane Database of Systematic Reviews. ,vol. 10, ,(2015) , 10.1002/14651858.CD010893.PUB2
Philip W. Peake, Timothy J. Pianta, Lena Succar, Mangalee Fernando, Nicholas A. Buckley, Zoltan H. Endre, Fab fragments of ovine antibody to colchicine enhance its clearance in the rat Clinical Toxicology. ,vol. 53, pp. 427- 432 ,(2015) , 10.3109/15563650.2015.1030026
Vikhyat S. Bebarta, David A. Tanen, Julio Lairet, Patricia S. Dixon, Sandra Valtier, Anneke Bush, Hydroxocobalamin and Sodium Thiosulfate Versus Sodium Nitrite and Sodium Thiosulfate in the Treatment of Acute Cyanide Toxicity in a Swine (Sus scrofa) Model Annals of Emergency Medicine. ,vol. 55, pp. 345- 351 ,(2010) , 10.1016/J.ANNEMERGMED.2009.09.020
Jean-Michel Scherrmann, Antibody treatment of toxin poisoning--recent advances. Clinical Toxicology. ,vol. 32, pp. 363- 375 ,(1994) , 10.3109/15563659409011037
Lily P.H. Yang, Oral colchicine (Colcrys): in the treatment and prophylaxis of gout. Drugs. ,vol. 70, pp. 1603- 1613 ,(2010) , 10.2165/11205470-000000000-00000
W. Schaumann, B. Kaufmann, P. Neubert, A. Smolarz, Kinetics of the Fab fragments of digoxin antibodies and of bound digoxin in patients with severe digoxin intoxication. European Journal of Clinical Pharmacology. ,vol. 30, pp. 527- 533 ,(1986) , 10.1007/BF00542410
Roger D Harris, Mark J Gillett, Colchicine poisoning—overview and new directions Emergency Medicine Australasia. ,vol. 10, pp. 161- 167 ,(2009) , 10.1111/J.1442-2026.1998.TB00674.X
M Eddleston, S Rajapakse, Rajakanthan, S Jayalath, L Sjöström, W Santharaj, PN Thenabadu, MHR Sheriff, DA Warrell, Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: a randomised controlled trial The Lancet. ,vol. 355, pp. 967- 972 ,(2000) , 10.1016/S0140-6736(00)90014-X
F. Dorandeu, J.R. Mikler, H. Thiermann, C. Tenn, C. Davidson, T.W. Sawyer, G. Lallement, F. Worek, Swine models in the design of more effective medical countermeasures against organophosphorus poisoning. Toxicology. ,vol. 233, pp. 128- 144 ,(2007) , 10.1016/J.TOX.2006.09.013