Charged residues are major determinants of the transmembrane orientation of a signal-anchor sequence.
作者： J P Beltzer , K Fiedler , I Geffen , M Spiess , H P Wessels
DOI: 10.1016/S0021-9258(17)35269-9
关键词: Signal peptide 、 Membrane protein 、 Biochemistry 、 Biophysics 、 Transmembrane protein 、 Amino acid 、 Membrane topology 、 Endoplasmic reticulum 、 Biology 、 Asialoglycoprotein receptor 、 Mutant protein
摘要: … To study the role of charged residues in determining the membrane topology, the … the charged amino acids flanking the hydrophobic signal were mutated to residues of opposite charge, …
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