Leucine and protein metabolism in rats with chronic renal insufficiency.
作者： M. Holeček , L. Šprongl , I. Tilšer , M. Tichý
关键词: Uremia 、 Endocrinology 、 Leucine 、 Metabolic disorder 、 Internal medicine 、 Acidosis 、 Biology 、 Isoleucine 、 Protein metabolism 、 Valine 、 Creatinine
摘要: Summary The aim of this study was to evaluate the effect chronic uremia induced by 5/6 nephrectomy (5/6NX) on changes in protein and branched-chain amino acid (BCAA; valine, leucine isoleucine) metabolism. control group consisted sham operated rats. Twenty eight weeks after surgery parameters metabolism were evaluated using a primed constant intravenous infusion L-[1- 14 C]leucine. A drop BCAA levels significant increase urea, creatinine cholesterol observed plasma all 5/6NX However, severe with acidosis developed only one third rats 5/6NX. In increases proteolysis, oxidation, oxidized fraction, clearance comparison without acidosis. addition, decrease valine concentration gastrocnemius muscle found. We conclude that marked activation proteolysis occurs renal failure is probably caused metabolic related development.
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