Transcriptome Analysis of CD133-positive Stem Cells and Prognostic Value of Survivin in Colorectal Cancer
作者： Amirali Talasaz , In-Gu Do , Insuk Sohn , Joon Oh Park , Jiryeon Jang
DOI:
关键词: Transcriptome 、 Survivin 、 Cell 、 Cancer research 、 Cancer stem cell 、 Gene expression profiling 、 Biomarker (medicine) 、 Stem cell 、 Colorectal cancer 、 Biology 、 Oncology 、 Internal medicine
摘要: Background/Aim: CD133 is an important, but not exclusive, biomarker of colorectal cancer (CRC) stem cells. Materials and Methods: In order to identify other CRC cell-specific genes, we performed a comparative expression profiling + - cell populations in primary metastatic tumors from four patients with CRC. cells were isolated using MagSweeper used for whole-transcriptome analysis RNA-Seq. Results: We found that cells, 17 genes (RNASE2, PRB2, IL4,
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