Pharmacokinetic modeling of the lung burden from repeated inhalation of nickel aerosols

摘要: Abstract The saturable nature of the clearance soluble nickel compounds from lung was studied by repeated exposures rats to respirable submicron-size aerosols. Using Michaelis-Menten type kinetics for removal burdens and a constant rate deposition, were simulated computer. computer simulation used design exposure regimen test further hypothesis clearance. Male Sprague-Dawley exposed 2 h/day chloride aerosols at either 90 or 400 μg Ni/m 3 up 14 days. During 22 h between days post-exposure kept in clean air. particle size aerosol ranged 0.7 0.9 μm mass median aerodynamic diameter with geometric standard deviation 1.2-1.4. A steady-state burden observed μg/m , as predicted modeling, while continued increase . best fit experimental data obtained maximum velocity ( V max ) 34.6 ng Ni/g · transport K 1 1380 Ni/g. percentage submicron retained 6.9%. These support mechanism provide physiological constants useful estimating human health risks inhalation.