A pharmacokinetic model of the intracellular dosimetry of inhaled nickel.

作者: C. Eric Hack , Tammie R. Covington , Greg Lawrence , Annette M. Shipp , Robinan Gentry

DOI: 10.1080/15287390600870726

关键词: Physiologically based pharmacokinetic modellingExtracellularChemistryIntracellularPathologyBioassayPharmacologyInhalationCarcinogenPharmacokineticsNickel

摘要: The potential associations between exposure to nickel compounds and cancer have been evaluated in both animal epidemiological studies of occupationally exposed workers. results the suggest that not all are equally carcinogenic, an observation supported by bioassay results. Given complexity differences modes uptake different forms cells subsequent delivery nucleus, it would be expected some more potent than others. A physiologically based pharmacokinetic (PBPK) model useful estimating cellular resulting from inhalation nickel. To this end, a preliminary tracheobronchial epithelial cell was developed describe extracellular intracellular kinetics classes compounds. Data available published literature were used define t...

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