Effects of short- and long-term estrogen and progesterone replacement on behavioral responses and c-fos mRNA levels in female rats after acute cocaine administration.
作者： Tipyamol Niyomchai , Shirzad Jenab , Eugene D. Festa , Alaleh Akhavan , Vanya Quiñones-Jenab
DOI: 10.1016/J.BRAINRES.2006.07.099
关键词: Biology 、 Endocrinology 、 Cell surface receptor 、 Mrna level 、 Messenger RNA 、 c-Fos 、 Chemotherapy 、 Internal medicine 、 Estrous cycle 、 Estrogen 、 Immediate early gene
摘要: It is well established that there are estrous cycle differences in cocaine-induced behavioral activity, implicating fluctuations levels of estrogen and progesterone throughout the these alterations behavior. However, mechanisms by which steroids alter responses have yet to be determined. The aim this study was determine whether short- or long-term administration differentially alters cocaine. Estrogen (50 μg) administered 30 min 48 h before cocaine (15 mg/kg, i.p.) administration; (500 24 Short-term replacement decreased ambulations. rearing, whereas Although increased c-fos mRNA, none paradigms affected measure. Because has been shown no effect on locomotor activity after acute administration, our observations suggest short-term may underlie alterations. These findings while activate only membrane receptors cocaine, activates both nuclear receptors.
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