Mechanisms of Oxidation of Hydrocarbons, Lipids and Low Density Lipoproteins
作者： N. A. Porter , C. M. Havrilla , J. A. Kenar
DOI: 10.1007/978-94-017-1607-9_9
关键词: Cholesterol 、 High-density lipoprotein 、 Internalization 、 Intracellular 、 Lipoprotein 、 Scavenger receptor 、 Biochemistry 、 Low-density lipoprotein 、 Lipoprotein oxidation 、 Chemistry
摘要: Low density lipoprotein (LDL) is the major carrier of cholesterol and its esters in human blood plasma. Free radical-peroxidation LDL may play a crucial role development atherosclerosis, much effort has been devoted to study oxidation prevention over last decade [1, 2]. Peroxidation LDL’s lipids affords hydroperoxides principally from cholesteryl linoleate (Ch18:2), predominant lipid component core [3]. Hydroperoxide formation generally thought precede result modification apoprotein B-100, single protein associated with LDL. Once modified, taken up by scavenger receptors monocyte-derived macrophages. Internalization this manner uncontrolled, leads intracellular accumulation appearance lipid-laden foam cells similar those found early atherosclerotic lesions.
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