Androgen-sensitive hypertension associated with soluble guanylate cyclase-α1 deficiency is mediated by 20-HETE

作者: Ana C Dordea , Sara Vandenwijngaert , Victor Garcia , Robert ET Tainsh , Daniel I Nathan

DOI: 10.1152/AJPHEART.00877.2015

关键词: 20-Hydroxyeicosatetraenoic acidCytochrome P450AndrogenBiologyEndocrinologyBlood pressureKnockout mouseATP synthaseEndothelial dysfunctionInternal medicineNitric oxide

摘要: Via linkage analysis, we identified Cyp4a12a, encoding the predominant murine synthase of vasoconstrictor 20-hydroxy-5,8,11,14-eicosatetraenoic acid (20-HETE), as a candidate sex-specific blood...

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