The Role of Pyrazinamide in Tuberculosis Chemotherapy
作者： Malcolm A. Steele , Roger M. Des Prez
关键词: Drug 、 Side effect 、 Pyrazinamide 、 Tuberculosis 、 Internal medicine 、 Chemotherapy regimen 、 Medicine 、 Chemotherapy 、 Salvage therapy 、 Isoniazid 、 Surgery
摘要: Pyrazinamide is an antituberculosis drug synthesized in the 1950s and formerly used only as salvage therapy. Recent developments have elevated it to a central role tuberculosis chemotherapy essential addition isoniazid rifampin which makes possible successfully complete treatment six months. This accomplished with no increase hepatotoxicity. The substantial side effect of this given at dosage for duration these six-month regimens polyarthralgia bothersome not sufficient warrant interruption More rarely, acute gout produced. early history pharmacology now first line are reviewed herein. (Chest 1988; 94:842-44)
chestjournal.org参考文章(55)
Ralph Tompsett, Walsh McDermott, Activation of pyrazinamide and nicotinamide in acidic environments in vitro. American review of tuberculosis. ,vol. 70, pp. 748- 754 ,(1954) , 10.1164/ART.1954.70.4.748
Max Salfinger, Felicitas M. Kafader, Susceptibility testing of Mycobacterium tuberculois to pyrazinamide Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology. ,vol. 265, pp. 404- 407 ,(1987) , 10.1016/S0176-6724(87)80259-6
A. J. Nunn, D. A. Mitchison, Influence of initial drug resistance on the response to short-course chemotherapy of pulmonary tuberculosis. The American review of respiratory disease. ,vol. 133, pp. 423- 430 ,(2015) , 10.1164/ARRD.1986.133.3.423
K. D. Stottmeier, G. P. Kubica, R. E. Beam, Determination of drug susceptibility of mycobacteria to pyrazinamide in 7H10 agar. The American review of respiratory disease. ,vol. 96, pp. 1072- ,(1967) , 10.1164/ARRD.1967.96.5.1072
Nicholas D. D'Esopo, Clinical trials in pulmonary tuberculosis. The American review of respiratory disease. ,vol. 125, pp. 85- 93 ,(1982) , 10.1164/ARRD.1982.125.3P2.85
I. M. Weiner, James P. Tinker, PHARMACOLOGY OF PYRAZINAMIDE: METABOLIC AND RENAL FUNCTION STUDIES RELATED TO THE MECHANISM OF DRUG-INDUCED URATE RETENTION Journal of Pharmacology and Experimental Therapeutics. ,vol. 180, pp. 411- 434 ,(1972)
Alfred J. Crowle, J. A. Sbarbaro, Mary H. May, Inhibition by pyrazinamide of tubercle bacilli within cultured human macrophages. The American review of respiratory disease. ,vol. 134, pp. 1052- 1055 ,(1986) , 10.1164/ARRD.1986.134.5.1052
Sunil S. Trivedi, S.G. Desai, Pyrazinamidase activity of Mycobacterium tuberculosis--a test of sensitivity to pyrazinamide. Tubercle. ,vol. 68, pp. 221- 224 ,(1987) , 10.1016/0041-3879(87)90058-4
Jean M. Dickinson, D.A. Mitchison, Bactericidal activity in vitro and in the guinea-pig of isoniazid, rifampicin and ethambutol. Tubercle. ,vol. 57, pp. 251- 258 ,(1976) , 10.1016/S0041-3879(76)80002-5
G Ellard, Observations on the reduction of the renal elimination of orate in man caused by the administration of pyrazinamide Tubercle. ,vol. 57, pp. 97- 103 ,(1976) , 10.1016/0041-3879(76)90046-5