Evaluation of fractions and isolated polysaccharides from Sasa veitchii for their preventive effects on influenza A virus infection
作者： Kyoko Hayashi , Jung-Bum Lee , Yukiyo Kurosaki , Mari Nozawa , Satomi Asai
DOI: 10.1016/J.JFF.2014.05.016
关键词: Lung 、 Virus 、 Influenza A virus 、 Bronchoalveolar lavage 、 Nitrite 、 Biology 、 Titer 、 Polysaccharide 、 Microbiology 、 Neutralizing antibody
摘要: The fractions and polysaccharides from Sasa veitchii were evaluated for their preventive effects on influenza A virus (IFV-A) infection. In IFV-A infected mice, the high-molecular portion (SH) of hot-water extract S. veitchii significantly reduced yields in lung bronchoalveolar lavage fluid (BALF) increased IFV-A-specific secretory IgA BALF intestine samples, neutralizing antibody titers BALFs sera. Separation SH by combination with ion-exchange column gel filtration yielded six purified polysaccharides. Among them, SH2A1B1 molecular weight 29.7 kDa was found to reduce as well IFV-A-infected mice. significant increase production also observed day 15 post-infection. Furthermore, enhancement nitrite oxide RAW 264.7 cells observed. These results suggest that could provide useful materials prevention
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