Surface anchored light chain bait antibody display system
作者： Hussam Hisham Saheen , Dongxing Zha
DOI:
关键词: Biophysics 、 Antigen 、 Molecular biology 、 Polynucleotide 、 Secretion 、 Covalent Interaction 、 Biology 、 Immunoglobulin light chain 、 Heavy chain 、 Antibody 、 Antibody molecule
摘要: The present invention provides, in part, an antibody display system that simultaneously uses a secretion and mode. Embodiments of the provide which bait complexed with monovalent fragment can be captured prior to host cell by virtue surface displaying light chain utilizing covalent interaction this heavy molecule is co-expressed same host. Polypeptides, polynucleotides cells useful for making are also provided along methods using identifying antibodies bind specifically antigen interest.
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