Production of glycoproteins with reduced o-glycosylation

作者: Piotr Bobrowicz , W. James Cook , Warren Kett

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摘要: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The includes the in cells cultured presence an inhibitor Pmt-mediated glycosylation and/or one or more α-1,2-mannosidases.

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