Good things come in small packages: Overcoming challenges to harness extracellular vesicles for therapeutic delivery
作者： Dominique Ingato , Jong Uk Lee , Sang Jun Sim , Young Jik Kwon
DOI: 10.1016/J.JCONREL.2016.09.016
关键词: Biochemical engineering 、 Extracellular vesicles 、 Nanotechnology 、 Current theory 、 Computer science
摘要: Extracellular vesicles (EVs) hold great promise as potential therapeutic carriers. EVs are biologically active, intrinsically transporting cargo between cells. Moreover, they can be loaded with specific for distribution and/or engineered to achieve enhanced uptake. Although studies have already demonstrated delivery using EVs, various challenges must overcome before EV technology is ready the clinic. Since properties of dependent upon their cell origin and conditions formation, establishing clear characterization practices essential ensuring reproducibility safety. Identifying methods mass production crucial achieving high yields necessary clinical trials. This review introduces current theory behind formation function, describes latest production, discusses future opportunities extracellular in delivery.
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